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Centenarian blood tests give hints of the secrets to longevity

<a href="https://theconversation.com/profiles/karin-modig-1473484">Karin Modig</a>, <a href="https://theconversation.com/institutions/karolinska-institutet-1250">Karolinska Institutet</a> Centenarians, once considered rare, have become commonplace. Indeed, they are the <a href="https://www.weforum.org/agenda/2021/02/living-to-one-hundred-life-expectancy/">fastest-growing demographic group</a> of the world’s population, with numbers roughly doubling every ten years since the 1970s. How long humans can live, and what determines a long and healthy life, have been of interest for as long as we know. Plato and Aristotle discussed and <a href="https://pubmed.ncbi.nlm.nih.gov/12092789/">wrote about the ageing process</a> over 2,300 years ago. The pursuit of understanding the secrets behind exceptional longevity isn’t easy, however. It involves <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105197/">unravelling the complex interplay</a> of genetic predisposition and lifestyle factors and how they interact throughout a person’s life. Now our recent study, <a href="https://link.springer.com/article/10.1007/s11357-023-00936-w">published in GeroScience</a>, has unveiled some common biomarkers, including levels of cholesterol and glucose, in people who live past 90. Nonagenarians and centenarians have long been of intense interest to scientists as they may help us understand how to live longer, and perhaps also how to age in better health. So far, studies of centenarians have often been small scale and focused on a selected group, for example, excluding centenarians who live in care homes. <h2>Huge dataset</h2> Ours is the largest study comparing biomarker profiles measured throughout life among exceptionally long-lived people and their shorter-lived peers to date. We compared the biomarker profiles of people who went on to live past the age of 100, and their shorter-lived peers, and investigated the link between the profiles and the chance of becoming a centenarian. Our research included data from 44,000 Swedes who underwent health assessments at ages 64-99 - they were a sample of <a href="https://pubmed.ncbi.nlm.nih.gov/28158674/">the so-called Amoris cohort</a>. These participants were then followed through Swedish register data for up to 35 years. Of these people, 1,224, or 2.7%, lived to be 100 years old. The vast majority (85%) of the centenarians were female. Twelve blood-based biomarkers related to inflammation, metabolism, liver and kidney function, as well as potential malnutrition and anaemia, were included. All of these <a href="https://www.nature.com/articles/s41591-019-0719-5">have been associated</a> with ageing or mortality in previous studies. The biomarker related to inflammation was uric acid – a waste product in the body caused by the digestion of certain foods. We also looked at markers linked to metabolic status and function including total cholesterol and glucose, and ones related to liver function, such as alanine aminotransferase (Alat), aspartate aminotransferase (Asat), albumin, gamma-glutamyl transferase (GGT), alkaline phosphatase (Alp) and lactate dehydrogenase (LD). We also looked at creatinine, which is linked to kidney function, and iron and total iron-binding capacity (TIBC), which is linked to anaemia. Finally, we also investigated albumin, a biomarker associated with nutrition. <h2>Findings</h2> We found that, on the whole, those who made it to their hundredth birthday tended to have lower levels of glucose, creatinine and uric acid from their sixties onwards. Although the median values didn’t differ significantly between centenarians and non-centenarians for most biomarkers, centenarians seldom displayed extremely high or low values. For example, very few of the centenarians had a glucose level above 6.5 earlier in life, or a creatinine level above 125. For many of the biomarkers, both centenarians and non-centenarians had values outside of the range considered normal in clinical guidelines. This is probably because these guidelines are set based on a younger and healthier population. When exploring which biomarkers were linked to the likelihood of reaching 100, we found that all but two (alat and albumin) of the 12 biomarkers showed a connection to the likelihood of turning 100. This was even after accounting for age, sex and disease burden. The people in the lowest out of five groups for levels of total cholesterol and iron had a lower chance of reaching 100 years as compared to those with higher levels. Meanwhile, people with higher levels of glucose, creatinine, uric acid and markers for liver function also decreased the chance of becoming a centenarian. In absolute terms, the differences were rather small for some of the biomarkers, while for others the differences were somewhat more substantial. For uric acid, for instance, the absolute difference was 2.5 percentage points. This means that people in the group with the lowest uric acid had a 4% chance of turning 100 while in the group with the highest uric acid levels only 1.5% made it to age 100. Even if the differences we discovered were overall rather small, they suggest a potential link between metabolic health, nutrition and exceptional longevity. The study, however, does not allow any conclusions about which lifestyle factors or genes are responsible for the biomarker values. However, it is reasonable to think that factors such as nutrition and alcohol intake play a role. Keeping track of your kidney and liver values, as well as glucose and uric acid as you get older, is probably not a bad idea. That said, chance probably plays a role at some point in reaching an exceptional age. But the fact that differences in biomarkers could be observed a long time before death suggests that genes and lifestyle may also play a role.<img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/215166/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /> <a href="https://theconversation.com/profiles/karin-modig-1473484">Karin Modig</a>, Associate Professor, Epidemiology, <a href="https://theconversation.com/institutions/karolinska-institutet-1250">Karolinska Institutet</a> Image credits: Shutterstock This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/centenarian-blood-tests-give-hints-of-the-secrets-to-longevity-215166">original article</a>.

Retirement Life

The US just returned to the Moon after more than 50 years. How big a deal is it, really?

<a href="https://theconversation.com/profiles/david-flannery-3906">David Flannery</a>, <a href="https://theconversation.com/institutions/queensland-university-of-technology-847">Queensland University of Technology</a> In the few short years since the COVID pandemic changed our world, China, Japan and India have all successfully landed on the Moon. Many more robotic missions have flown past the Moon, entered lunar orbit, or crashed into it in the past five years. This includes <a href="https://www.planetary.org/space-missions/kplo">spacecraft developed by South Korea</a>, <a href="https://english.alarabiya.net/News/gulf/2023/04/27/Dubai-s-ruler-announces-new-moon-mission-after-UAE-s-Rashid-Rover-lunar-crash-">the United Arab Emirates</a>, and an <a href="https://www.spaceil.com/">Israeli not-for-profit organisation</a>. Late last week, the American company <a href="https://www.intuitivemachines.com/">Intuitive Machines</a>, in collaboration with NASA, celebrated “America’s return to the Moon” with a successful landing of its Odysseus spacecraft. Recent <a href="https://theconversation.com/change-5-china-launches-sample-return-mission-to-the-moon-is-it-winning-the-new-space-race-150665">Chinese-built sample return missions</a> are far more complex than this project. And didn’t NASA ferry a dozen humans to the Moon back when microwaves were cutting-edge technology? So what is different about this mission developed by a US company? <h2>Back to the Moon</h2> The recent Odysseus landing stands out for two reasons. For starters, this is the first time a US-built spacecraft has landed – not crashed – on the Moon for over 50 years. Secondly, and far more significantly, this is the first time a private company has pulled off a successful delivery of cargo to the Moon’s surface. NASA has lately focused on destinations beyond the Earth–Moon system, including Mars. But with its <a href="https://www.nasa.gov/commercial-lunar-payload-services/">Commercial Lunar Payload Services</a> (CLPS) program, it has also funded US private industry to develop Moon landing concepts, hoping to reduce the delivery costs of lunar payloads and allow NASA engineers to focus on other challenges. Working with NASA, Intuitive Machines selected a <a href="https://en.wikipedia.org/wiki/Malapert_(crater)">landing site</a> about 300 kilometres from the lunar south pole. Among other challenges, landing here requires entering a polar orbit around the Moon, which consumes additional fuel. At this latitude, the land is heavily cratered and dotted with long shadows. This makes it challenging for autonomous landing systems to find a safe spot for a touchdown. NASA spent about US$118 million (A$180 million) to land six scientific <a href="https://www.esa.int/Enabling_Support/Space_Engineering_Technology/About_Payload_Systems">payloads</a> on Odysseus. This is relatively cheap. Using low-cost lunar landers, NASA will have an efficient way to test new space hardware that may then be flown on other Moon missions or farther afield. <h2>Ten minutes of silence</h2> One of the technology tests on the Odysseus lander, NASA’s <a href="https://www.nasa.gov/directorates/stmd/impact-story-navigation-doppler-lidar/">Navigation Doppler Lidar experiment</a> or NDL, appears to have proved crucial to the lander’s success. As the lander neared the surface, the company realised its navigation systems had a problem. NASA’s NDL experiment is serendipitously designed to test precision landing techniques for future missions. It seems that at the last second, engineers bodged together a solution that involved feeding necessary data from NDL to the lander. Ten minutes of silence followed before a <a href="https://twitter.com/Int_Machines/status/1760838333851148442">weak signal was detected</a> from Odysseus. Applause thundered through the mission control room. NASA’s administrator released a video congratulating everyone for returning America to the Moon. It has since become clear the lander is not oriented perfectly upright. The solar panels are generating sufficient power and the team is slowly receiving the first images from the surface. However, it’s likely Odysseus <a href="https://www.universetoday.com/165864/odysseus-moon-lander-is-tipped-over-but-still-sending-data/">partially toppled over</a> upon landing. Fortunately, at the time of writing, it seems most of the science payload may yet be deployed as it’s on the side of the lander facing upwards. The unlucky payload element facing downwards <a href="https://edition.cnn.com/2024/02/23/world/odysseus-lunar-landing-sideways-scn/index.html">is a privately contributed artwork</a> connected <a href="https://edition.cnn.com/2024/02/22/style/jeff-koons-moon-phases-odysseus-landing/index.html">to NFTs</a>. The lander is now likely to survive for at least a week before the Sun sets on the landing site and a dark, frigid lunar night turns it into another museum piece of human technology frozen in the lunar <a href="https://www.britannica.com/science/regolith">regolith</a>. <h2>Win some, lose some</h2> NASA’s commercial approach to stimulating low-cost payload services all but guarantees some failures. But eventually NASA hopes that several commercial launch and landing providers will emerge from the program, along with a few learning experiences. The know-how accumulated at organisations operating hardware in space is at least as important as the development of the hardware itself. The market for commercial lunar payloads remains unclear. Possibly, once the novelty wears off and brands are no longer able to generate buzz by, for example, <a href="https://www.columbia.com/omni-heat-infinity/moon-mission/">sending a piece of outdoor clothing to the Moon</a>, this source of funding may dwindle. However, just as today, civil space agencies and taxpayers will continue to fund space exploration to address shared science goals. Ideally, commercial providers will offer NASA an efficient method for testing key technologies needed for its schedule of upcoming scientific robotic missions, as well as <a href="https://www.nasa.gov/specials/artemis/">human spaceflight in the Artemis program</a>. Australia would also have the opportunity to test hardware at a reduced price. It’s worth noting that US budgetary issues, <a href="https://spacenews.com/nasa-warns-of-very-problematic-space-technology-budget-cuts/">funding cuts</a> and <a href="https://www.jpl.nasa.gov/news/jpl-workforce-update">subsequent lay-offs</a> do threaten these ambitions. Meanwhile, in Australia, we may have nothing to launch anyway. We continue to spend less <a href="https://www.aph.gov.au/About_Parliament/Parliamentary_departments/Parliamentary_Library/Budget/reviews/2023-24/ScienceResearch">than the OECD average on scientific research</a>, and only a few Australian universities – who traditionally lead such efforts – <a href="https://business.gov.au/grants-and-programs/moon-to-mars-initiative-demonstrator-mission-grants/grant-recipients">have received funding</a> provided by the Australian Space Agency. If we do support planetary science and space exploration in the future, Australians will need to decide if we want to allocate our limited resources, competing with NASA and US private industry, to supply launch, landing and robotic services to the global space industry. Alternatively, we could leverage these lower-cost payload providers to develop our own scientific space program, and locally developed space technologies associated with benefits to the knowledge economy, education and national security.<img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/224276/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /> <a href="https://theconversation.com/profiles/david-flannery-3906">David Flannery</a>, Planetary Scientist, <a href="https://theconversation.com/institutions/queensland-university-of-technology-847">Queensland University of Technology</a> Image credits: Intuitive Machines This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/the-us-just-returned-to-the-moon-after-more-than-50-years-how-big-a-deal-is-it-really-224276">original article</a>.

International Travel

8 reasons everyone should know their blood type

Why you should know your blood type What’s in a blood type? Potentially a lot, according to research, including a review of studies published in the Wiley Interdisciplinary Reviews: Systems Biology and Medicine, that connects different blood groups to everything from risk of heart disease and dementia to urinary tract infections and the norovirus. While none of the studies are conclusive about cause and effect (they can’t say X blood type causes Y disease) and any increased risks are still pretty small, the research does highlight the importance of knowing your type – A, B, AB, or O – and how it could affect your wellbeing. Blood clots: Type AB, A, and B increases risk Danish researchers studied how blood type interacts with a genetic predisposition for deep-vein thrombosis (DVT), or blood clots in the lower legs that can travel to the lungs and become life-threatening. After analysing data on about 66,000 people over more than 30 years, they found that those with type AB, A, or B had a 40 per cent higher risk of DVT than people with type O, the most common type. When the scientists did further analysis to see which factors have the biggest impact on DVT risk on a population level, they found that an AB blood type contributed to about 20 per cent of blood clots; genetic mutations accounted for 11 per cent, being overweight accounted for 16 per cent, and smoking accounted for six per cent. Heart disease: Type AB, B, and A all increase risk People whose blood type is A, B, or AB have an increased risk of heart disease and shorter life spans than people who have type O blood, according to a large study published in BMC Medicine. After following more than 50,000 middle-age and elderly people for seven years, on average, researchers found that as many as nine per cent of cardiovascular deaths were attributed to having non-O blood types. However, as any doctor will tell you, lifestyle factors like weight, smoking and diet, which, unlike blood type, are modifiable, have a much greater impact on heart disease. Stomach cancer: Types A and AB increases risk Researchers have known for a while that people with blood type A are at risk for stomach cancer. But research published in BMC Cancer shows that people with blood type AB are also at risk. Using genetic data from a large number of cases and controls, researchers found a link between both blood types and gastric cancer in Chinese populations. A review of 39 previous studies confirmed their findings. Fertility: Type O reduces it Women with this blood type were twice as likely to have blood levels of the hormone FSH high enough to indicate low ovarian reserve, a measure of fertility, according to a study published in Human Reproduction. Researchers couldn’t say for sure why, though. Given that type O blood is the most prevalent, it doesn’t pay to worry too much about it. Age is a far more important risk factor for fertility problems. Pregnancy risks This has nothing to do with your “letter” blood type or the type determined by the ABO grouping system. This has to do with what’s known as the Rhesus (Rh) factor, which determines whether your blood type is positive or negative. This could cause complications in pregnant women if the baby’s Rh blood type is different from the mother’s. For instance, if the mother has a negative blood type and the baby has a positive one, the mother’s body can actually build up antibodies against the baby’s blood type. Luckily, this doesn’t affect the baby, but it could have a negative effect on future pregnancies. Fortunately, doctors can give pregnant women a shot early in their pregnancy that can prevent Rh-incompatibility problems. Dementia and memory loss: Type AB increases risk People with type AB blood have an 82 per cent greater risk for cognitive decline later in life, according to a study published in Neurology. That’s likely because they have larger amounts of what’s known as the Factor VIII protein, which helps with blood clotting. Study participants with higher levels of this protein were 24 per cent more likely to develop memory problems – regardless of their blood type – than people with lower levels. Blood type, however, is far from the only, or even most important, factor that affects your risk for cognitive decline. Stroke: Type O has the lowest risk People with a blood type other than O (the most common) have a higher risk of cardiovascular issues such as stroke, according to a study published in the Journal of Thrombosis and Haemostasis. Biologists are still investigating why this might be; one possible explanation is that non-O blood types contain more of the Von Willebrand factor, a protein that has been connected to blood clotting and stroke in the past. Mosquitos like Type O blood If you find yourself scratching bug bites all summer long, your blood type might be to blame. In a one small study, researchers found that type Os are up to twice as attractive to mosquitoes as type As, with type Bs falling somewhere in the middle. Image credits: Shutterstock This article originally appeared on <a href="https://www.readersdigest.com.au/healthsmart/8-reasons-everyone-should-know-their-blood-type" target="_blank" rel="noopener">Reader's Digest</a>.

Body

"I've lost complete blood flow": Robert Irwin's near miss with python

Young wildlife warrior Robert Irwin suffered a near miss during a rescue mission over the weekend, when he tried to relocate a carpet python off the road. The 19-year-old took to Instagram on Sunday to share a video of him almost getting bit by the wild snake. "Gee, that gets the heart rate up - he missed me by that much," he said when the snake struck at him. "He's grumpy... he's really keen on biting me... what a gorgeous snake, he's big, he's not venomous but... they're designed to constrict," he said as the python began wrapping its body around his arm to ''constrict" him. "He's got a good grip there, I've lost complete blood flow to my hand, it's completely blue.. and I have no feeling left in my hand," he added. He eventually managed to rescue the snake, and relocated it to a safe spot in the bush the day after. "Near miss! Definitely had a good laugh with this grumpy carpet python - but great to get him rescued off the road and relocated to a much safer spot!" he captioned the post. <blockquote class="instagram-media" style="background: #FFF; border: 0; border-radius: 3px; box-shadow: 0 0 1px 0 rgba(0,0,0,0.5),0 1px 10px 0 rgba(0,0,0,0.15); margin: 1px; max-width: 540px; min-width: 326px; padding: 0; width: calc(100% - 2px);" data-instgrm-captioned="" data-instgrm-permalink="https://www.instagram.com/reel/C0Fc3k-hiy9/?utm_source=ig_embed&utm_campaign=loading" data-instgrm-version="14"> <div style="padding: 16px;"> <div style="display: flex; flex-direction: row; align-items: center;"> <div style="background-color: #f4f4f4; border-radius: 50%; flex-grow: 0; height: 40px; margin-right: 14px; width: 40px;"> </div> <div style="display: flex; flex-direction: column; flex-grow: 1; justify-content: center;"> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; margin-bottom: 6px; width: 100px;"> </div> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; width: 60px;"> </div> </div> </div> <div style="padding: 19% 0;"> </div> <div style="display: block; height: 50px; margin: 0 auto 12px; width: 50px;"> </div> <div style="padding-top: 8px;"> <div style="color: #3897f0; font-family: Arial,sans-serif; font-size: 14px; font-style: normal; font-weight: 550; line-height: 18px;">View this post on Instagram</div> </div> <div style="padding: 12.5% 0;"> </div> <div style="display: flex; flex-direction: row; margin-bottom: 14px; align-items: center;"> <div> <div style="background-color: #f4f4f4; border-radius: 50%; height: 12.5px; width: 12.5px; transform: translateX(0px) translateY(7px);"> </div> <div style="background-color: #f4f4f4; height: 12.5px; transform: rotate(-45deg) translateX(3px) translateY(1px); width: 12.5px; flex-grow: 0; margin-right: 14px; margin-left: 2px;"> </div> <div style="background-color: #f4f4f4; border-radius: 50%; height: 12.5px; width: 12.5px; transform: translateX(9px) translateY(-18px);"> </div> </div> <div style="margin-left: 8px;"> <div style="background-color: #f4f4f4; border-radius: 50%; flex-grow: 0; height: 20px; width: 20px;"> </div> <div style="width: 0; height: 0; border-top: 2px solid transparent; border-left: 6px solid #f4f4f4; border-bottom: 2px solid transparent; transform: translateX(16px) translateY(-4px) rotate(30deg);"> </div> </div> <div style="margin-left: auto;"> <div style="width: 0px; border-top: 8px solid #F4F4F4; border-right: 8px solid transparent; transform: translateY(16px);"> </div> <div style="background-color: #f4f4f4; flex-grow: 0; height: 12px; width: 16px; transform: translateY(-4px);"> </div> <div style="width: 0; height: 0; border-top: 8px solid #F4F4F4; border-left: 8px solid transparent; transform: translateY(-4px) translateX(8px);"> </div> </div> </div> <div style="display: flex; flex-direction: column; flex-grow: 1; justify-content: center; margin-bottom: 24px;"> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; margin-bottom: 6px; width: 224px;"> </div> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; width: 144px;"> </div> </div> <p style="color: #c9c8cd; font-family: Arial,sans-serif; font-size: 14px; line-height: 17px; margin-bottom: 0; margin-top: 8px; overflow: hidden; padding: 8px 0 7px; text-align: center; text-overflow: ellipsis; white-space: nowrap;"><a style="color: #c9c8cd; font-family: Arial,sans-serif; font-size: 14px; font-style: normal; font-weight: normal; line-height: 17px; text-decoration: none;" href="https://www.instagram.com/reel/C0Fc3k-hiy9/?utm_source=ig_embed&utm_campaign=loading" target="_blank" rel="noopener">A post shared by Robert Irwin (@robertirwinphotography)</a> </div> </blockquote> Fans shared their shock and couldn't help but comment on how much the young conservationist was like his late father, Steve Irwin. "Dude you are killing us with these like-father-like-son bits," one fan wrote. "Holy crap. I actually thought I was watching Steve for a second and it took me back a moment. He's very much still alive in his family. No doubt about that," another added. "This is precarious yet hiss-terical !😂 all at the same time. Thank you for helping snakey dude slither to safety! 👍🏼💕" added a fellow conservationist. Images: Instagram

Travel Trouble

Worried about getting a blood test? 5 tips to make them easier (and still accurate)

<a href="https://theconversation.com/profiles/sapha-shibeeb-1481231">Sapha Shibeeb</a>, <a href="https://theconversation.com/institutions/rmit-university-1063">RMIT University</a> Blood tests are a common medical procedure, offering valuable insights into a person’s health. Whether you’re getting a routine check-up, diagnosing a medical condition or monitoring treatment progress, understanding the process can make the experience more comfortable and effective. For the majority of patients, blood collections are a minor inconvenience. Others may feel <a href="https://www.sciencedirect.com/science/article/abs/pii/S0887618506000041">uneasy and anxious</a>. Preparation strategies can help get you through the procedure. <h2>How blood is collected</h2> During venipuncture (blood draw), the phlebotomist (blood collector) inserts a needle through the skin into a vein and a small amount of blood is collected and transferred into a test tube. Tubes are sent to a laboratory, where the blood is analysed. A laboratory technician may count or examine cells and measure the levels of minerals/salts, enzymes, proteins or other substances in the sample. For some tests, blood plasma is separated out by spinning (centrifuging) the sample. Others pass a light beam through the sample to determine the amount of a chemical present. For collection, the phlebotomist usually selects a vein in the crook of your elbow, where veins are readily accessible. Blood can also be drawn from veins in the wrists, fingers or heels. A tourniquet may be applied to restrict blood flow and make the chosen vein puff out. <h2>Different tests require different preparation</h2> Before a blood test, the GP or health-care provider will give you specific instructions. These may include fasting for up to 12 hours or temporarily discontinuing certain medications. It is crucial to follow these guidelines meticulously as they can significantly impact the accuracy of your test results. For example, fasting is required before glucose (blood sugar) and lipids (blood fats) testing because blood sugar and cholesterol levels typically increase after a meal. If the blood test requires fasting, you will be asked not to eat or drink (no tea, coffee, juice or alcohol) for about eight to 12 hours. Water is allowed but smoking should be avoided because it can increase <a href="https://diabetesjournals.org/care/article/19/2/112/19825/Acute-Effect-of-Cigarette-Smoking-on-Glucose">blood sugar, cholesterol and triglyceride levels</a>. Generally, you will be asked to fast overnight and have the blood collection done in the morning. Fasting for longer than 15 hours could impact your results, too, by causing dehydration or the release of certain chemicals in the blood. If you have diabetes, you must consult your doctor prior to fasting because it can increase the risk of hypoglycemia (low blood sugar) in people with type 1 diabetes. Most type 2 diabetics can safely fast before a blood test but there are some exceptions, such as people who are taking certain medications including insulin. <h2>5 tips for a better blood test</h2> To improve your blood collection experience, consider these tips: 1. Hydrate Drink plenty of water right up to 30 minutes before your appointment. Adequate hydration improves blood flow, making your veins more accessible. Avoid <a href="https://academic.oup.com/labmed/article/34/10/736/2657269">strenuous exercise</a> before your blood test, which can increase some blood parameters (such as liver function) while decreasing others (such as sodium). 2. Loose clothing Wear clothing that allows easy access to your arms to ensure a less stressful procedure. 3. Manage anxiety If the sight of blood or the procedure makes you anxious, look away while the needle is inserted and try to keep breathing normally. Distraction can help – virtual reality has been <a href="https://pubmed.ncbi.nlm.nih.gov/31889358/">trialled</a> to reduce needle anxiety in children. You could try bringing something to read or music to listen to. 4. Know your risk of fainting If you’re prone to fainting, make sure to inform the phlebotomist when you arrive. You can have your blood drawn while lying down to minimise the risk of passing out and injury. Hydration helps maintain blood pressure and can also <a href="https://www.ahajournals.org/doi/10.1161/01.CIR.0000101966.24899.CB">reduce the risk</a> of fainting. 5. Discuss difficult veins Some people have smaller or scarred veins, often due to repeated punctures, <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4989034/">chemotherapy</a> or blood thinner use. In such cases, venipuncture may require multiple attempts. It is important to talk to the phlebotomist if you feel discomfort or significant pain. A finger prick can be performed as an alternative for some tests, such as blood glucose levels. But other comprehensive tests require larger blood volume. <h2>Blood draws after lymph node removal</h2> Historically, there were concerns about drawing blood from an arm that had undergone lymph node removal. This was due to the risk of <a href="https://www.cancer.gov/about-cancer/treatment/side-effects/lymphedema/lymphedema-pdq#:%7E:text=Lymphedema%20is%20the%20build%2Dup,the%20way%20that%20it%20should.">lymphedema</a>, a condition marked by fluid build-up in the affected arm. Lymph nodes may have been removed (<a href="https://www.ncbi.nlm.nih.gov/books/NBK564397/#:%7E:text=Lymph%20node%20dissection%2C%20also%20known,surgical%20management%20of%20malignant%20tumors.">lymphadenectomy</a>) for cancer diagnosis or treatment. However, a <a href="https://ascopubs.org/doi/10.1200/JCO.2015.61.5948">2016 study</a> showed people who’ve had lymph nodes removed are not at a higher risk of developing lymphedema following blood draws, even when drawing blood from the affected arm. <h2>After your blood test</h2> The whole blood test procedure usually lasts no more than a few minutes. Afterwards, you may be asked to apply gentle pressure over a clean dressing to aid clotting and reduce swelling. If you do experience swelling, bruising or pain after a test, follow general first aid procedures to alleviate discomfort. These include applying ice to the site, resting the affected arm and, if needed, taking a pain killer. It is usually recommended you do not do heavy lifting for a few hours after a blood draw. This is to prevent surges in blood flow that could prevent clotting where the blood was taken.<img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/216073/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /> <a href="https://theconversation.com/profiles/sapha-shibeeb-1481231">Sapha Shibeeb</a>, Senior lecturer in Laboratory Medicine , <a href="https://theconversation.com/institutions/rmit-university-1063">RMIT University</a> Image credits: Shutterstock This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/worried-about-getting-a-blood-test-5-tips-to-make-them-easier-and-still-accurate-216073">original article</a>.

Body

Almost half of Moon missions fail. Why is space still so hard?

<a href="https://theconversation.com/profiles/gail-iles-761554">Gail Iles</a>, <a href="https://theconversation.com/institutions/rmit-university-1063">RMIT University</a> In 2019, India attempted to land a spacecraft on the Moon – and ended up painting a kilometres-long streak of debris on its barren surface. Now the Indian Space Research Organisation has returned in triumph, with the Chandrayaan-3 lander <a href="https://www.reuters.com/world/india/india-counts-down-crucial-moon-landing-2023-08-23/">successfully touching down</a> near the south pole of Earth’s rocky neighbour. India’s success came just days after a <a href="https://www.nature.com/articles/d41586-023-02659-6">spectacular Russian failure</a>, when the Luna 25 mission tried to land nearby and “ceased to exist as a result of a collision with the lunar surface”. These twin missions remind us that, close to 60 years after the first successful “soft landing” on the Moon, spaceflight is still difficult and dangerous. Moon missions in particular are still a coin flip, and we have seen several high-profile failures in recent years. Why were these missions unsuccessful and why did they fail? Is there a secret to the success of countries and agencies who have achieved a space mission triumph? <h2>An exclusive club</h2> The Moon is the only celestial location humans have visited (so far). It makes sense to go there first: it’s the closest planetary body to us, at a distance of around 400,000 kilometres. Yet only four countries have achieved successful “soft landings” – landings which the spacecraft survives – on the lunar surface. The USSR was the first. The <a href="https://en.wikipedia.org/wiki/Luna_9">Luna 9</a> mission safely touched down on the Moon almost 60 years ago, in February 1966. The United States followed suit a few months later, in June 1966, with the <a href="https://www.smithsonianmag.com/air-space-magazine/1966-the-real-first-moon-landing-118785850/">Surveyor 1</a> mission. China was the next country to join the club, with the <a href="https://en.wikipedia.org/wiki/Chang%27e_3">Chang'e 3</a> mission in 2013. And now India too has arrived, with <a href="https://amp.theguardian.com/science/2023/aug/23/india-chandrayaan-3-moon-landing-mission">Chandrayaan-3</a>. Missions from Japan, the United Arab Emirates, Israel, Russia, the European Space Agency, Luxembourg, South Korea and Italy have also had <a href="https://en.wikipedia.org/wiki/List_of_missions_to_the_Moon">some measure of lunar success</a> with fly-bys, orbiters and impacts (whether intentional or not). <h2>Crashes are not uncommon</h2> On August 19 2023, the Russian space agency Roscosmos announced that “communication with the <a href="https://www.nature.com/articles/d41586-023-02659-6">Luna 25 spacecraft</a> was interrupted”, after an impulse command was sent to the spacecraft to lower its orbit around the Moon. Attempts to contact the spacecraft on August 20 were unsuccessful, leading Roscosmos to determine Luna 25 had crashed. Despite more than 60 years of spaceflight experience extending from the USSR to modern Russia, this mission failed. We don’t know exactly what happened – but the current situation in Russia, where resources are stretched thin and tensions are high due to the ongoing war in Ukraine, may well have been a factor. The Luna 25 failure recalled two high-profile lunar crashes in 2019. In April that year, the Israeli <a href="https://en.wikipedia.org/wiki/Beresheet">Beresheet lander</a> crash-landed after a gyroscope failed during the braking procedure, and the ground control crew was unable to reset the component due to a loss of communications. It was later reported a capsule containing microscopic creatures called tardigrades, in a dormant “cryptobiotic” state, may have survived the crash. And in September, India sent its own Vikram lander down to the surface of the Moon – but it did not survive the landing. NASA later <a href="https://www.theguardian.com/science/2019/dec/03/indias-crashed-vikram-moon-lander-spotted-on-lunar-surface">released an image</a> taken by its Lunar Reconnaissance Orbiter showing the site of the Vikram lander’s impact. Debris was scattered over almost two dozen locations spanning several kilometres. <h2>Space is still risky</h2> Space missions are a risky business. Just over <a href="https://www.businessinsider.in/science/space/news/success-rate-of-lunar-missions-is-a-little-over-50-as-per-nasa-database/articleshow/101774227.cms">50% of lunar missions succeed</a>. Even <a href="https://ntrs.nasa.gov/api/citations/20190002705/downloads/20190002705.pdf">small satellite missions</a> to Earth’s orbit don’t have a perfect track record, with a success rate somewhere between 40% and 70%. We could compare uncrewed with crewed missions: around <a href="https://www.bbc.com/future/article/20230518-what-are-the-odds-of-a-successful-space-launch">98% of the latter are successful</a>, because people are more invested in people. Ground staff working to support a crewed mission will be more focused, management will invest more resources, and delays will be accepted to prioritise the safety of the crew. We could talk about the details of why so many uncrewed missions fail. We could talk about technological difficulties, lack of experience, and even the political landscapes of individual countries. But perhaps it’s better to step back from the details of individual missions and look at averages, to see the overall picture more clearly. <h2>The big picture</h2> Rocket launches and space launches are not very common in the scheme of things. There are <a href="https://www.pd.com.au/blogs/how-many-cars-in-the-world/">around 1.5 billion cars</a> in the world, and perhaps <a href="https://www.travelweek.ca/news/exactly-many-planes-world-today/">40,000 aeroplanes</a>. By contrast, there have been fewer than <a href="https://planet4589.org/space/gcat/data/derived/launchlog.html">20,000 space launches</a> in all of history. Plenty of things still go wrong with cars, and problems occur even in the better-regulated world of planes, from loose rivets to computers overriding pilot inputs. And we have more than a century of experience with these vehicles, in every country on the planet. So perhaps it’s unrealistic to expect spaceflight – whether it’s the launch stage of rockets, or the even rarer stage of trying to land on an alien world – to have ironed out all its problems. We are still very much in the early, pioneering days of space exploration. <h2>Monumental challenges remain</h2> If humanity is ever to create a fully fledged space-faring civilisation, we must <a href="https://www.wired.com/2016/02/space-is-cold-vast-and-deadly-humans-will-explore-it-anyway/">overcome monumental challenges</a>. To make long-duration, long-distance space travel possible, there are a huge number of problems to be solved. Some of them seem within the realm of the possible, such as better radiation shielding, self-sustaining ecosystems, autonomous robots, extracting air and water from raw resources, and zero-gravity manufacturing. Others are still speculative hopes, such as faster-than-light travel, instantaneous communication, and artificial gravity. Progress will be little by little, small step by slightly larger step. Engineers and space enthusiasts will keep putting their brainpower, time and energy into space missions, and they will gradually become more reliable. And maybe one day we’ll see a time when going for a ride in your spacecraft is as safe as getting in your car. <hr /> Correction: a typing error in the original version of this article put the Surveyor 1 mission in 1996, rather than its actual year of 1966.<img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/211914/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /> <a href="https://theconversation.com/profiles/gail-iles-761554">Gail Iles</a>, Senior Lecturer in Physics, <a href="https://theconversation.com/institutions/rmit-university-1063">RMIT University</a> Image credits: Shutterstock This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/almost-half-of-moon-missions-fail-why-is-space-still-so-hard-211914">original article</a>.

International Travel

No, you can’t reverse ageing by injecting ‘young blood’ and fasting. But that doesn’t stop people trying

<a href="https://theconversation.com/profiles/rachael-jefferson-buchanan-297850">Rachael Jefferson-Buchanan</a>, <a href="https://theconversation.com/institutions/charles-sturt-university-849">Charles Sturt University</a> Like many celebrities and entrepreneurs, 45-year-old US tech billionaire Bryan Johnson is <a href="https://www.smh.com.au/lifestyle/health-and-wellness/taking-the-blood-of-your-17-year-old-son-anti-ageing-has-gone-too-far-20230530-p5dcd6.html">trying to reverse the ageing process</a>. Spending an average of US$2 million a year on an anti-ageing regimen, Johnson <a href="https://medium.com/future-literacy/at-45-i-now-age-slower-than-the-average-10-year-old-6932448fc608">claims</a> he now ages slower than some children. He explains: “the pace my body accumulates ageing damage is less than the average ten year old”. Many of Johnson’s age-reversal methods are questionable, involve dodgy science, and have known side effects. While you can’t stop the ageing process, and the gradual decline our bodies experience as we advance in years, there are some things we can all do – for free – to maintain our health as we age. <h2>What does Johnson do? And is it scientific?</h2> Fasting Johnson reports fasting for 23 hours a day. He then eats <a href="https://medium.com/future-literacy/one-meal-23-hr-fast-100-nutrition-18187a2f5b">one meal a day</a>: 2,250 calories of nutrient-dense food “customised” to his body’s needs. Eating for time-restricted periods in the day can have a <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9650338/">positive effect</a> on how we <a href="https://pubmed.ncbi.nlm.nih.gov/29955217/">metabolise nutrients</a>, inflammation levels, hormonal regulation, and <a href="https://www.health.harvard.edu/blog/how-good-is-your-cardiometabolic-health-and-what-is-that-anyway-202208182803">cardiometabolic health</a> (blood sugar, <a href="https://www.mayoclinic.org/diseases-conditions/high-blood-cholesterol/in-depth/triglycerides/art-20048186">triglycerides</a>, cholesterol, blood pressure, BMI and waist circumference). However, a Spartan-like food intake can <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2121099/">impair</a> how our body responds to sugar (known as glucose tolerance). And it’s not necessarily any more effective for weight maintenance than <a href="https://pubmed.ncbi.nlm.nih.gov/29419624/">reducing calorie intake at each meal</a>. Large-scale, long-term human trials are needed to confirm the <a href="https://pubmed.ncbi.nlm.nih.gov/34728336/">limited risk-benefit</a> findings of fasting. Acid peels Johnson has weekly <a href="https://www.asds.net/skin-experts/skin-treatments/chemical-peels/chemical-peels-for-aging-skin">acid peels</a> (which use a mild acid to exfoliate the skin) to maintain a “youthful glow”. But you cannot smooth sagging facial skin or remove deep scars or wrinkles. Acid peels also <a href="https://www.mayoclinic.org/tests-procedures/chemical-peel/about/pac-20393473">come with risks</a>, including organ damage, infection, scarring and swelling. Plasma infusions Perhaps the most bizarre youth-inducing procedure Johnson has attempted is receiving blood transfusions from his 17-year-old son. US biotech companies have explored <a href="https://www.theguardian.com/society/2020/feb/02/could-young-blood-stop-us-getting-old-transfusions-experiments-mice-plasma">plasma infusions</a> to tackle age-related diseases in humans for decades. But there are no proven clinical benefits. <a href="https://www.redcrossblood.org/donate-blood/blood-donation-process/what-happens-to-donated-blood/blood-transfusions/risks-complications.html">Side effects from blood transfusions</a> include blood-borne infections, fever and allergic reactions. <h2>Historical attempts to stay youthful</h2> Humans have been experimenting with <a href="https://academic.oup.com/biomedgerontology/article/59/6/B515/662071">anti-ageing methods for centuries</a>. These have included all sorts of behavioural and lifestyle practices that are quirky, questionable, and even sadistic. Ancient practices included <a href="https://www.marieclaire.com/beauty/news/a14382/anti-aging-beauty-through-history/">crocodile dung face masks</a>, which the Greeks and Romans used to brighten their complexions. Romans also used <a href="https://beautytap.com/2019/03/donkey-milk">donkey milk</a> and <a href="https://www.ancient-origins.net/history/swans-fat-crocodile-dung-and-ashes-snails-achieving-beauty-ancient-rome-003240">swan fat</a> to minimise wrinkles, due to their acclaimed rejuvenating properties. <a href="https://www.livescience.com/44071-cleopatra-biography.html">Cleopatra</a> apparently took daily baths in sour donkey milk. To sustain this lavish habit, she had a <a href="https://www.naturanecosmetics.com/en/content/26-faits-historiques">herd of 700 donkeys</a>. Sour milk contains <a href="https://science.jrank.org/pages/3780/Lactic-Acid-Lactic-acid-in-foods.html">lactic acid</a>, a naturally occurring <a href="https://www.mecca.com.au/edits/ingredients/alpha-hydroxy-acids/">alpha-hydroxy acid (AHA)</a> that exists in many modern-day exfoliants. So this idea was grounded in basic science, at least. <figure class="align-center "><img src="https://images.theconversation.com/files/530478/original/file-20230607-27-bv0w1t.jpg?ixlib=rb-1.1.0&q=45&auto=format&w=754&fit=clip" sizes="(min-width: 1466px) 754px, (max-width: 599px) 100vw, (min-width: 600px) 600px, 237px" srcset="https://images.theconversation.com/files/530478/original/file-20230607-27-bv0w1t.jpg?ixlib=rb-1.1.0&q=45&auto=format&w=600&h=400&fit=crop&dpr=1 600w, https://images.theconversation.com/files/530478/original/file-20230607-27-bv0w1t.jpg?ixlib=rb-1.1.0&q=30&auto=format&w=600&h=400&fit=crop&dpr=2 1200w, https://images.theconversation.com/files/530478/original/file-20230607-27-bv0w1t.jpg?ixlib=rb-1.1.0&q=15&auto=format&w=600&h=400&fit=crop&dpr=3 1800w, https://images.theconversation.com/files/530478/original/file-20230607-27-bv0w1t.jpg?ixlib=rb-1.1.0&q=45&auto=format&w=754&h=503&fit=crop&dpr=1 754w, https://images.theconversation.com/files/530478/original/file-20230607-27-bv0w1t.jpg?ixlib=rb-1.1.0&q=30&auto=format&w=754&h=503&fit=crop&dpr=2 1508w, https://images.theconversation.com/files/530478/original/file-20230607-27-bv0w1t.jpg?ixlib=rb-1.1.0&q=15&auto=format&w=754&h=503&fit=crop&dpr=3 2262w" alt="Milk bath with dried fruits and flowers" /><figcaption>Don’t waste milk on a bath. <a class="source" href="https://www.shutterstock.com/image-photo/bath-milk-flowers-1051210370">Shutterstock</a></figcaption></figure> During the 16th and 17th century, “Countess Dracula” aka <a href="https://en.wikipedia.org/wiki/Elizabeth_B%C3%A1thory">Elizabeth Bathory</a> allegedly resorted to serial killing to quench her thirst for youthfulness, <a href="https://www.nationalgeographic.com/travel/article/the-bloody-legend-of-hungarys-serial-killer-countess">bathing in the blood of her young victims</a>. <h2>The quest continues with cryotherapy</h2> Fountain of youth fixations have inspired many contemporary anti-ageing trends. Exposure to cold is a firm favourite. <a href="https://www.nature.com/articles/s43587-023-00383-4">Some research</a> suggests this could have <a href="https://neurosciencenews.com/cold-aging-22928/">benefits</a> relating to longevity, by slowing cellular degeneration, <a href="https://www.cryo.com.au/anti-ageing-benefits-of-whole-body-cryotherapy/">stimulating collagen and elastin production</a>, increasing the metabolism, and reducing inflammation. Dutch motivational speaker Wim Hof includes <a href="https://www.wimhofmethod.com/cold-water-immersion">cold water immersion</a> as one of the three pillars of his <a href="https://www.wimhofmethod.com/">Wim Hof Method</a> to “increase mind-body connection”. Athletes such as <a href="https://www.dailymail.co.uk/sport/football/article-2469985/Cristiano-Ronaldo-buys-Cryotherapy-chamber.html">Cristiano Ronaldo</a> use <a href="https://my.clevelandclinic.org/health/treatments/21099-cryotherapy">cryotherapy</a>, exposing their bodies to extremely cold temperatures for two to four minutes to decrease the signs of ageing and enhance their general health. However, the <a href="https://www.medicinenet.com/what_are_the_side_effects_of_cryotherapy/article.htm">risks of cryotherapy</a> include bone fractures, frostbite, nerve damage, bleeding, cramping, swelling and skin infections. <h2>So what can we do to age well?</h2> Two of the more mainstream anti-ageing methods that Johnson recommends are the daily self-care habits of sleep and exercise. He has a <a href="https://medium.com/future-literacy/sleep-and-impulse-control-87e844218ff2">strict sleep schedule</a> that involves retiring to bed at 8pm, with a one-hour wind-down in a darkened room. Adults report poorer sleep quality and difficulty being able to sleep for long enough <a href="https://www.news-medical.net/health/How-Does-the-Suprachiasmatic-Nucleus-(SCN)-Control-Circadian-Rhythm.aspx">as they age</a>. Sleeping too much or too little is <a href="https://www.frontiersin.org/articles/10.3389/fpubh.2023.1043347/full">associated with</a> a greater risk of obesity, heart disease and <a href="https://theconversation.com/research-check-can-sleeping-too-much-lead-to-an-early-death-101323">premature death</a>. Developing a regular sleep routine, reducing bedroom distractions such as mobile phones, and exercising regularly can all help to <a href="https://www.sleepfoundation.org/aging-and-sleep">alleviate sleep problems</a>. <figure class="align-center "><img src="https://images.theconversation.com/files/530491/original/file-20230607-29-cw0f29.jpg?ixlib=rb-1.1.0&q=45&auto=format&w=754&fit=clip" sizes="(min-width: 1466px) 754px, (max-width: 599px) 100vw, (min-width: 600px) 600px, 237px" srcset="https://images.theconversation.com/files/530491/original/file-20230607-29-cw0f29.jpg?ixlib=rb-1.1.0&q=45&auto=format&w=600&h=383&fit=crop&dpr=1 600w, https://images.theconversation.com/files/530491/original/file-20230607-29-cw0f29.jpg?ixlib=rb-1.1.0&q=30&auto=format&w=600&h=383&fit=crop&dpr=2 1200w, https://images.theconversation.com/files/530491/original/file-20230607-29-cw0f29.jpg?ixlib=rb-1.1.0&q=15&auto=format&w=600&h=383&fit=crop&dpr=3 1800w, https://images.theconversation.com/files/530491/original/file-20230607-29-cw0f29.jpg?ixlib=rb-1.1.0&q=45&auto=format&w=754&h=482&fit=crop&dpr=1 754w, https://images.theconversation.com/files/530491/original/file-20230607-29-cw0f29.jpg?ixlib=rb-1.1.0&q=30&auto=format&w=754&h=482&fit=crop&dpr=2 1508w, https://images.theconversation.com/files/530491/original/file-20230607-29-cw0f29.jpg?ixlib=rb-1.1.0&q=15&auto=format&w=754&h=482&fit=crop&dpr=3 2262w" alt="Child and grandfather walk on a beach" /><figcaption>Exercise is also important for healthy ageing. <a class="source" href="https://unsplash.com/photos/s-vhziQHngM">Vidar Nordi Mathisen/Unsplash</a></figcaption></figure> Exercise, often cited as a <a href="https://www.marketwatch.com/story/exercise-is-the-wonder-drug-for-healthy-aging-11633642719">wonder drug for healthy ageing</a>, is something Johnson takes very seriously. He does a “<a href="https://www.youtube.com/watch?v=HNywRJgCRaQ">Blueprint</a>” workout that includes specially designed daily techniques, as well as <a href="https://www.hsph.harvard.edu/nutritionsource/high-intensity-interval-training/">high-intensity interval training sessions</a>, hiking and playing sport. From middle age onwards, we all need to exercise regularly, to increase our muscle mass, bone density, strength, endurance, coordination and balance. One of the greatest health risks for older people is <a href="https://www.ncbi.nlm.nih.gov/books/NBK560761/">falling</a>, which balance, flexibility, endurance and strength training <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC381224/">can help</a> reduce. Physical activity can bring <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5408452/">social benefits</a> in older adults if undertaken in groups, and there are well-known <a href="https://www.whiddon.com.au/yourlife/the-mental-health-benefits-of-exercise-for-older-adults/">mental health gains</a>. Small changes in sleep, diet (eating <a href="https://health.gov/news/202107/nutrition-we-age-healthy-eating-dietary-guidelines">plenty of vegetables, fruit, wholegrains, healthy fats, and enough protein</a>), and exercise can support <a href="https://bmcgeriatr.biomedcentral.com/articles/10.1186/s12877-020-01900-5">healthy ageing</a>, reducing the chance of early death, and helping us all to lead an active and independent life in our senior years. Now that is something worth investing in.<img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/207038/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /> <a href="https://theconversation.com/profiles/rachael-jefferson-buchanan-297850">Rachael Jefferson-Buchanan</a>, Lecturer in Human Movement Studies (Health and PE) and Creative Arts, <a href="https://theconversation.com/institutions/charles-sturt-university-849">Charles Sturt University</a> This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/no-you-cant-reverse-ageing-by-injecting-young-blood-and-fasting-but-that-doesnt-stop-people-trying-207038">original article</a>. Images: Getty

Body

Leo DiCaprio's new film gets 9-minute standing ovation

If a 9-minute standing ovation is anything to go by, then claims that Martin Scorsese’s new project Killers of the Flower Moon is the “film of the year” may just be on to something. The movie - which stars the likes of Hollywood legends Leonardo DiCaprio, Robert De Niro, and Lily Gladstone - received exactly that: 9 whole minutes of applause after its world premiere at the 2023 Cannes Film Festival. Its stars were all in attendance, from Leo who was last present with Once Upon a Time … in Hollywood, to 80-year-old Scorsese, who was returning to the festival for the first time since 1985, when he was there for After Hours. The near-three-and-a-half-hour film - which shares its name with the David Grann book it was adapted from - takes place in 1920s Oklahoma, and shares the story of a dark period in American history, depicting the serial murders of members of the Osage Nation. Prior to its screening, the film had already been dubbed by some as the festival’s “most anticipated film” - it even saw Apple CEO Tim Cook swing by, as the company is one of the film’s distributors. And as soon as it concluded, the applause broke out - with some suspecting that it may have continued on beyond the 9-minute mark, had Scorsese not been asked to address the crowd. <blockquote class="twitter-tweet"> Leonardo DiCaprio and Lily Gladstone land a 9-minute standing ovation for ‘Killers of the Flower Moon’ — the biggest and loudest of <a href="https://twitter.com/hashtag/Cannes2023?src=hash&ref_src=twsrc%5Etfw">#Cannes2023</a> so far. <a href="https://t.co/1Gxp4cED1T">pic.twitter.com/1Gxp4cED1T</a> — Ramin Setoodeh (@RaminSetoodeh) <a href="https://twitter.com/RaminSetoodeh/status/1660019896393113602?ref_src=twsrc%5Etfw">May 20, 2023</a></blockquote> “Thank you to the Osages,” Scorsese said upon reaching the mic. “Everyone connected with the picture. My old pals Bob and Leo, and Jesse and Lily. We shot this a couple of years ago in Oklahoma. “It’s taken it’s time to come around but Apple did so great by us. There was lots of grass. I’m a New Yorker. I was very surprised. This was an amazing experience. “We lived in that world with the Osage, we really did, and we really miss it.” As former Osage tribal leader Jim Gray said of the experience, “the dignity and care for the Osage perspective was genuine and honest throughout the process and the Osage responded with the kind of passion and enthusiasm that met this historic moment. “For those of us who were watching from the sidelines while our best and brightest among us auditioned, sewed, catered, painted, acted and advised the filmmakers, it’s going to be hard not to feel our presence in helping to tell.” Lily Gladstone - who plays an Osage woman betrayed by her husband in the movie - had more to add, telling Variety that “the work is better when you let the world inform the work. That was very refreshing how involved the production got with the [Osage Nation] community. As the community warmed up to our presence, the more the community got involved with the film. “It’s a different movie than the one [Scorsese] walked in to make almost entirely because of what the community had to say about how it was being made and what was being portrayed.” And alongside praise for the film came praise for the performances within it, with many convinced Gladstone is set for attention during awards season for her work, and one reviewer even going so far as to call this “Leonardo DiCaprio’s best performance yet”. Images: Getty

Movies

Molly Meldrum “moons” crowd again

New footage has emerged of music icon Ian “Molly” Meldrum appearing to expose himself before urinating on the floor at a Rod Steward concert. The Daily Mail Australia published a video and images of Meldrum, 80, allegedly pulling out his genitalia and relieving himself while he was seated in the crowd at Melbourne’s Rod Laver Arena. “There were people everywhere. It was disgusting,” a witness told the outlet. The indecent exposure comes after Meldrum sparked heavy backlash after <a href="https://www.oversixty.com.au/entertainment/music/a-naughty-boy-who-needs-a-new-belt-molly-meldrum-s-excuse-for-mooning-elton-john-s-crowd" target="_blank" rel="noopener">“mooning” the audience while on stage at an Elton John performance.</a> Entertainment reporter Peter Ford addressed the situation on 2GB’s Ben Fordham Live. “He has an acquired brain injury, we have to accept that,” he told the host, referencing Meldrum’s fall from a ladder in 2011. “Molly’s always been given to sort of odd behaviour, but since that fall – which he almost died as a result of – his judgment has been impaired.” Ford said he wasn’t “making excuses for bad behaviour”, and that Meldrum’s minders needed to take action. “I do think they’ve got to look at what’s happening when he goes out on these excursions, because he’s not being supervised enough or he’s not taking that supervision or guidance. It’s not like he’s turning up at these events on his own.” He went on to say he’d been given some insight into the shocking behind-the-scenes situation after Meldrum’s infamous Elton John stunt. “I know after the last public incident with Elton, his closest minder called me and was furious with me for reporting the story,” Ford revealed. “And they reminded me very clearly, the guy’s got an acquired brain injury – we take him out, and we can’t control what happens after that.” Image credit: Getty

Mind

The Dark Side of the Moon at 50: how Marx, trauma and compassion all influenced Pink Floyd’s masterpiece

Dixi et salvavi animam meam. This Latin phrase – I have spoken and saved my soul – sits at the end of Karl Marx’s <a href="https://www.marxists.org/archive/marx/works/1875/gotha/">Critique of the Gotha Programme</a>. Written in 1875, this text imagines a communist society that will come about “after the enslaving of the individual to the division of labour, and thereby also the antithesis between mental and physical labour has vanished”. Only then, Marx argues, “can the narrow horizon of bourgeois right be completely transcended and society inscribe on its banners: from each according to his abilities, to each according to his needs!” Roger Waters – bassist, lyricist and conceptual mastermind behind Pink Floyd’s 1973 album The Dark Side of the Moon, released 50 years ago today – knows Marx’s Critique. Indeed, he quotes it when discussing the record with music journalist John Harris. “Making The Dark Side of the Moon, we were all trying to do as much as we possibly could,” Waters <a href="https://www.goodreads.com/en/book/show/301401">told</a> Harris. "It was a very communal thing. What’s that old Marxist maxim? ‘From each according to his ability, to each according to his need.’ That’s sort of the way the band worked at that point." Assertions about solidarity, cooperation and shared “unity of purpose” – as Waters says – situate Dark Side in the context of Pink Floyd’s <a href="https://faroutmagazine.co.uk/pink-floyd-roger-waters-david-gilmour-feud/">notoriously fractious</a> recording career and helps us understand the album’s enduring appeal. <h2>Shine on you crazy diamond</h2> Pink Floyd formed in London in 1965. Led by the charismatic songwriter, guitarist and lead vocalist Syd Barrett, the group established itself as a leader in the <a href="https://en.wikipedia.org/wiki/UK_underground">London underground music scene</a>. They released their debut album The Piper at the Gates of Dawn in 1967. <a href="https://en.wikipedia.org/wiki/Soft_Machine">Soft Machine</a> member Kevin Ayers <a href="https://www.bloomsbury.com/au/pink-floyds-the-piper-at-the-gates-of-dawn-9781441185174/">described</a> The Piper at the Gates of Dawn as “something magical, but it was in Syd Barrett”. Not long after the record’s release, Barrett suffered a catastrophic, LSD-induced breakdown. In response, the band recruited David Gilmour on guitar and recorded a second album, A Saucerful of Secrets, as a five-piece in 1968. Around this time, the increasingly unstable Barrett was unceremoniously ousted by the rest of the band. After Barrett left, says Ayers, “Pink Floyd became something else totally”. There are different versions of Pink Floyd. The recordings released after Barrett left the band in 1968 bear little resemblance to the first. Dark Side sounds nothing like the whimsical Piper. But it is obvious the record is in large part preoccupied with the loss of Barrett. This preoccupation comes to the fore in the album’s penultimate track. <a href="https://www.youtube.com/watch?v=g1OOQP1-wOE&ab_channel=HDPinkFloyd">Brain Damage</a>, written and sung by Waters, references Barrett’s adolescence (“Remembering games and daisy chains and laughs”), alludes to his illness (“And if the dam breaks open many years too soon”), and acknowledges his leaving the group (“And if the band you’re in starts playing different tunes; I’ll see you on the dark side of the Moon”). Drummer Nick Mason confirms the group didn’t want to lose Barrett. In his <a href="https://www.goodreads.com/book/show/265734.Inside_Out">autobiography</a>, he writes, "He was our songwriter, singer, guitarist, and – although you might not have known from our less than sympathetic treatment of him – he was our friend." <h2>If the dam breaks open many years too soon</h2> What we hear on The Dark Side of the Moon is a band dealing with trauma. In this sense, Dark Side represents the start of a reckoning with the past – a process that culminated with the band’s next record, 1975’s elegiac <a href="https://faroutmagazine.co.uk/wish-you-were-here-pink-floyd-seminal-ode-to-the-tragic-life-of-syd-barrett/">Wish You Were Here</a>. Culmination is a useful term when it comes to Dark Side more generally. On this record, all the avant-garde techniques and tendencies the band had toyed with in the post-Barrett period – <a href="https://en.wikipedia.org/wiki/Musique_concr%C3%A8te">musique concrète</a>, sonic manipulation, extended improvisation, analogue tape manipulation – come together to spectacular effect. <a href="https://www.youtube.com/watch?v=-0kcet4aPpQ">Money</a> – with its anti-capitalist lyrics penned by Waters (“Money, it’s a crime; share it fairly, but don’t take a slice of my pie”), odd time signature, and handmade tape-loops mimicking the sounds of cash tills, bags of coins being dropped from great height and bank notes being torn up – is one of the stranger hit singles in pop music history. Be that as it may, Money and the album from which it is taken, of which <a href="https://www.pinkfloyd.com/tdsotm50/">more than 50 million copies</a> have been sold, continue to resonate with listeners worldwide, five decades on from its initial release. <h2>The enormous risk of being truly banal</h2> “I made a conscious effort when I was writing the lyrics for Dark Side of the Moon to take the enormous risk of being truly banal about a lot of it,” Waters told John Harris, “in order that the ideas should be expressed as simply and plainly as possible.” On this point, <a href="https://www.loudersound.com/news/david-gilmour-says-its-pretty-unlikely-he-and-roger-waters-will-resolve-pink-floyd-feud">if nothing else</a>, David Gilmour agrees. He told Harris, "There was definitely a feeling that the words were going to be very clear and specific. That was a leap forward. Things would mean what they meant. That was a distinct step away from what we had done before." Mortality, insanity, conflict, affluence, poverty and, in another nod to Marx, <a href="https://en.wikipedia.org/wiki/Marx%27s_theory_of_alienation">alienation</a> are some of the themes presented on the record. The need – and this brings us full circle – for compassion, if not outright solidarity, is another. This is an album about the importance of understanding, as Waters <a href="https://www.goodreads.com/en/book/show/301401">insists, "T</a>he potential that human beings have for recognising each other’s humanity and responding to it, with empathy rather than antipathy." Given the sorry state of the world in 2023, about which Roger Waters has many <a href="https://www.bbc.com/news/entertainment-arts-64580688">contentious</a> and <a href="https://www.theguardian.com/music/2023/feb/07/pink-floyd-lyricist-calls-roger-waters-an-antisemite-and-putin-apologist">problematic</a> things to say, I wager Pink Floyd’s masterwork will continue to resonate with listeners for a while yet. Image credits: Getty Images This article originally appeared on <a href="https://theconversation.com/the-dark-side-of-the-moon-at-50-how-marx-trauma-and-compassion-all-influenced-pink-floyds-masterpiece-198400" target="_blank" rel="noopener">The Conversation</a>.

Music

“A naughty boy who needs a new belt”: Molly Meldrum’s excuse for mooning Elton John’s crowd

Music TV legend Molly Melrdum has apologised profusely for his onstage behaviour after gatecrashing Sir Elton John's Farewell show in Melbourne on Friday. But the excuse he has proffered did not find much by way of support among sceptics. Meldrum blamed what happened while standing braced alongside Sir Elton’s piano … on a wardrobe malfunction. On Friday night, Meldrum left onlookers bewildered and taken aback when his trousers suddenly dropped without warning, meaning he effectively mooned the packed audience. The legendary music critic and presenter has now gone on record as saying that it was all due to a wardrobe malfunction involving his faulty belt. “I shouldn’t have crashed Elton’s show,” Meldrum told the Herald Sun. “As for my performance being more revealing than it should have been … well, at the start of the night, my belt buckle broke and my pants were already falling down. And on stage, one thing led to another.” Prior to the incident, Molly had been in the audience taking in the show – but since both he and Sir Elton have been lifelong friends, the star of the show gave a special tribute to Meldrum, saying, "He’s quite honestly a national treasure. I want to thank him for all the love and loyalty he’s shown me over the years. I love you." Meldrum took that as his cue to mount the stage, and the pair then performed “The Bitch Is Back” together, before the now-infamous wardrobe malfunction occurred – which Sir Elton appears not to even realise is happening. It’s then that Molly chooses to really go with the moment, lifting his jacket and showing his backside even further, before finally pulling up his trousers. <blockquote class="twitter-tweet"> If seeing Molly Meldrum’s bare bum was on your 2023 bingo card, here you go. (From tonight’s Elton John concert at AAMI Park Melbourne) <a href="https://t.co/7B7OYZWhgl">pic.twitter.com/7B7OYZWhgl</a> — Tish (@oztish) <a href="https://twitter.com/oztish/status/1613862887029886978?ref_src=twsrc%5Etfw">January 13, 2023</a></blockquote> "I feel terrible if any of the security people get in trouble,” Molly then said the following day. “The whole thing was 100 per cent my idea – no one else knew what I was doing. Elton might have been singing The Bitch is Back, but it was more a case of The Idiot is Back. "I just hope my antics didn’t detract from a truly spectacular show and Elton’s fabulous farewell. No one is to blame apart from me. “Elton is an icon and a legend. I’m just a naughty boy, who needs a new belt.” Images: @oztish / Twitter

Music

Big study shows that lowering blood pressure lowers risk of dementia

A study across 20 countries has strengthened a link between lowering blood pressure, and reducing the risk of dementia. The meta-analysis, published in the European Heart Journal, draws on clinical trial data from 28,008 participants, to show the strongest link to date between medication that lowers blood pressure, and reduced dementia risk. “We know that high blood pressure is a risk factor for dementia – especially high blood pressure in midlife, so say 40 to 65 years of age,” says lead author Dr Ruth Peters, an associate professor at the University of New South Wales and program lead for dementia in the George Institute’s Global Brain Health Initiative. “But there has been some uncertainty about whether lowering blood pressure, especially in older adults, would reduce risk of dementia. “What we’ve done is take five really high-quality clinical trials and combine them into one dataset, which gave us the ability to really look at this question and look at the relationship between blood pressure-lowering tablets – antihypertensives – and dementia.” The five studies were all double-blind, randomised clinical trials – the ‘gold standard’ in medical research – with participants hailing from 20 different countries. The average age of the participants was 69, and participants were followed up an average of four years after doing the trial. Participants who took antihypertensives had a significantly lower chance of being diagnosed with dementia than those who took placebos. Dementia affects 50 million people worldwide: a number projected to triple by 2050. According to The Lancet’s 2020 Commission on dementia, treatment for hypertension (high blood pressure) is “the only known effective preventive medication for dementia,” all other methods of reducing your risk come from lifestyle and environment. “The strength of this study is the use of individual patient data in a meta-analysis of data drawn from randomised controlled trials of blood pressure medication. This is the first time such data has been meta-analysed,” says Professor Kaarin Anstey, a senior principal research scientist at Neuroscience Research Australia and the UNSW. “This is important for informing clinical practice,” adds Anstey, who was not involved with the study. Professor Nicolas Cherbuin, head of the Australian National University’s Centre for Research on Ageing, Health and Wellbeing, says that the study is “well-designed”, and reflects research by his team showing that higher blood pressure is linked to lower brain volumes and poorer brain health. “The diagnostic procedure and criteria used are well-established, the sample size is large, those with dementia at baseline were excluded,” says Cherbuin. But he points out that the study didn’t find an effect of blood pressure medication on cognitive decline, and nor did it include participants with mild cognitive impairment, who would be “more likely to convert”. Anstey points out that “inevitably” the participants in the cohort are now quite old, and thus may be different to populations developing dementia now. “Clinical trials involve highly selected samples and often exclude diverse ethnic groups,” she adds. “I hope that this reinforces the importance of blood pressure control for brain health,” says Peters. But she emphasises that, while this is useful news for preventing dementia in mid-life, people of all ages can improve their brain health by other means. “It’s not just blood pressure lowering – it has to be taken in the context of a healthy lifestyle.” This article originally appeared on <a href="https://cosmosmagazine.com/health/dementia-blood-pressure-meta/" target="_blank" rel="noopener">cosmosmagazine.com</a> and was written by Ellen Phiddian. Image: Shutterstock

Body

Shehan Karunatilaka wins Booker prize for Sri Lankan political satire, The Seven Moons of Maali Almeida

Sri Lankan novelist Shehan Karunatilaka has won the 2022 Booker Prize for his second novel, The Seven Moons of Maali Almeida. The win couldn’t come at a better time for Sri Lanka, a country once more engaged in <a href="https://foreignpolicy.com/2022/10/06/sri-lanka-economic-crisis-protests-imf/" target="_blank" rel="noopener">political and economic instability</a>, as it suffers through one of the world’s worst economic crises, with soaring inflation, food and fuel shortages, and low supplies of foreign reserves. And of course, the government was overthrown in July, after President Gotabaya Rajapaksa fled following mass protests. Karunatilaka said in his acceptance speech: <blockquote> My hope for Seven Moons is this; that in the not-too-distant future, 10 years, as long as it takes, Sri Lanka […] has understood that these ideas of corruption and race-baiting and cronyism have not worked and will never work. </blockquote> <h2>Political black comedy</h2> Karunatilaka’s novel is extraordinary – and hard to pin down. It is at once a black comedy about the afterlife, a murder mystery whodunit, and a political satire set against the violent backdrop of the late-1980s Sri Lankan civil war. It is also a story of love and redemption. Malinda “Maali” Kabalana, a closeted war photographer, wakes up dead in what seems to be a celestial waiting room. The setting will be familiar to many who’ve spent time in Colombo (as I have – it’s where my husband’s family is from). We open in a busy, bureaucratic office, filled with confusion, noise, a propensity against queuing – and a healthy dose of “gallows” humour. In other words, Maali is in some sort of purgatory. Maali soon discovers he has seven days – seven moons – to solve his own murder. This isn’t easy – he is interrupted by sardonic ghosts (often with grudges, questionable motives, and a tendency towards extreme chattiness), the violent reality of war-torn Colombo, and piecing together his memories of who he was. He also has seven moons to lead his official girlfriend and his secret boyfriend to a cache of photographs, taken over time, which document the horror of the war – and incriminate local and foreign governments. Karunatilaka’s subject matter and plot highlight, question and explore Sri Lanka’s legacy – and its continued, difficult relationship with its civil war, which spanned 1983 to 2009, though the reverberations continue. And his novel’s provocative, intimate, second-person style implicates us – the readers. Karunatilaka has mastered his craft as a novelist. He never once wavers from a second-person perspective that might be unwieldy (perhaps even gimmicky) in a lesser writer’s hands. The novel tells us, “Don’t try and look for the good guys, ‘cause there ain’t none”. It realises a combined responsibility for the tragedy of that 25-year civil war, in which the country’s colonial history is also implicated. British colonialists brought Tamil workers from South India to Sri Lanka, to work as indentured labourers on their coffee, tea and rubber plantations. Their descendants’ fight for an independent Tamil state was a strong component of the civil war. <h2>Diffusing violence with humour</h2> As a novelist and lover of second-person narration and a long-time follower of Karuntailaka’s accomplished work, I couldn’t be more delighted by this Booker win. I first came across Karunatilaka through his debut novel, <a href="https://www.penguin.com.au/books/chinaman-9780099555681" target="_blank" rel="noopener">Chinaman</a>, which was handed to me by my sister-in-law several years ago on a family visit to Colombo. That book taught me about cricket, but it also taught me the sardonic brilliance of Sri Lankan humour. Karunatilaka once again uses humour to great effect in The Seven Moons of Maali Almeida – to diffuse confronting moments of violence, to engage his reader, and for pure enjoyment. This novel follows a murder victim through a bloody civil war – and it’s laugh-out-loud funny. It’s also a tighter, more focused book than Chinaman: here is an author in control of his craft and what he wants to say with it. The Booker judges, too, praised the “scope and the skill, the daring, the audacity and hilarity” of the book. Karunatilaka’s winning novel took time to write. Ten years have passed since Chinaman. His skilful use of craft to tell this complicated story is testament to the idea that good books take the time they need: something that all authors know but publishers are not always willing to accept. However, Karunatilaka has been busy in that ten years, not just writing literary fiction, but writing for children – and having a family. The 47-year-old is now married with two kids. Karunatilaka is only the second Sri Lankan novelist to have won the Booker Prize. (The first was Michael Ondaatje in 1992 for The English Patient.) But last year, his countryman Anuk Arudpragasam was also <a href="https://thebookerprizes.com/the-booker-library/authors/anuk-arudpragasam" target="_blank" rel="noopener">shortlisted</a>, for <a href="https://www.allenandunwin.com/browse/book/Anuk-Arudpragasam-Passage-North-9781783786961" target="_blank" rel="noopener">A Passage North</a>, another accomplished novel set in the aftermath of the civil war. I’m excited by what this means for Sri Lankan authors and the Sri Lankan publishing scene. Here is a country with stories to tell and enormous skill to tell them with: let’s hope this leads to more Sri Lankan novels achieving wide readership, success and deserved acclaim. This article originally appeared on <a href="https://theconversation.com/shehan-karunatilaka-wins-booker-prize-for-sri-lankan-political-satire-the-seven-moons-of-maali-almeida-192722" target="_blank" rel="noopener">The Conversation</a>. Image: thebookerprizes.com

Books

Scientists have mimicked an embryo’s heart to unlock the secrets of how blood cells are born

Stem cells are the starting point for all other cells in our bodies. The <a href="https://www.eurostemcell.org/blood-stem-cells-pioneers-stem-cell-research" target="_blank" rel="noopener">first such cells to be found</a> were blood stem cells – as the name suggests, they give rise to different types of blood cells. But there’s much we don’t know about how these cells develop in the first place. In a study published today in <a href="https://doi.org/10.1016/j.celrep.2022.111339" target="_blank" rel="noopener">Cell Reports</a>, we have shown how a lab simulation of an embryo’s beating heart and circulation lead to the development of human blood stem cell precursors. The tiny device mimics embryonic blood flow, allowing us to directly observe human embryonic blood formation under the microscope. These results may help us understand how we can produce life-saving therapies for patients who need new blood stem cells. <h2>Growing life-saving therapies in the lab</h2> To treat aggressive blood cancers such as leukaemia, patients often need extremely high doses of chemotherapy; a <a href="https://www.cancer.nsw.gov.au/myeloma/diagnosis-and-treatment/treatment/types-of-treatment/stem-cell-transplant#:%7E:text=A%20stem%20cell%20transplant%20involves%20killing%20blood%20cells,they%20are%20collected%20beforehand%20and%20kept%20in%20storage." target="_blank" rel="noopener">blood stem cell transplant</a> then regenerates blood after the treatment. These are life-saving therapies but are restricted to patients who have a suitable tissue-matched donor of blood stem cells. A way around this problem would be to grow more blood stem cells in the lab. Unfortunately, past experiments have shown that harvested adult blood stem cells lose their transplantation potential if grown in the lab. The discovery of <a href="https://en.wikipedia.org/wiki/Induced_pluripotent_stem_cell" target="_blank" rel="noopener">induced pluripotent stem cells</a> – stem cells made out of adult cells – in 2006 led to a promising new approach. Induced pluripotent stem cells are made from the patient’s own cells, so there is no problem with tissue rejection, or the ethical issues surrounding the use of IVF embryos. These cell lines are similar to embryonic stem cells, so they have the potential to form any tissue or cell type – hence, they are “pluripotent”. In theory, pluripotent stem cell lines could provide an unlimited supply of cells for blood regeneration because <a href="https://en.wikipedia.org/wiki/Immortalised_cell_line" target="_blank" rel="noopener">they are immortalised</a> – they can grow in the lab indefinitely. But the development of processes to allow us to grow particular types of tissues, organs and cell types – such as blood – has been slow and will take decades to advance. One must mimic the complex process of embryogenesis in the dish! <h2>Engineering an embryonic heart</h2> Current understanding of how embryonic blood stem cells develop is based on animal models. Experiments with anaesthetised zebrafish embryos have shown that blood stem cells arise in the wall of <a href="https://pubmed.ncbi.nlm.nih.gov/20154733/" target="_blank" rel="noopener">the main blood vessel, the aorta</a>, shortly after the first heartbeat. For ethical reasons, it’s obvious this type of study is not possible in human embryos. This is why we wanted to engineer an embryonic heart model in the lab. To achieve this, we used <a href="https://www.elveflow.com/microfluidic-reviews/general-microfluidics/a-general-overview-of-microfluidics/" target="_blank" rel="noopener">microfluidics</a> – an approach that involves manipulating extremely small volumes of liquids. The first step in generating blood stem cells from pluripotent stem cells is to coax the latter to form the site where blood stem cells start growing. This is known as the AGM region (aorta-gonad-mesonephros) of the embryo. Our miniature heart pump and circulation (3 by 3 centimetres) mimics the mechanical environment in which blood stem cells form in the human embryo. The device pumps culture media – liquids used to grow cells – around a microfluidic circuit to copy what the embryo heart does. <h2>A step closer to treatment</h2> Once we got the cells to form the AGM region by stimulating cells on day two of starting our cell culture, we applied what’s known as pulsatile circulatory flow from day 10 to day 26. Blood precursors entered the artificial circulation from blood vessels lining the microfluidic channels. Then, we harvested the circulating cells and grew them in culture, showing that they developed into various blood components – white blood cells, red blood cells, platelets, and others. In-depth analysis of gene expression in single cells showed that circulatory flow generated aortic and blood stem precursor cells found in the AGM of human embryos. This means our study has shown how pulsatile circulatory flow enhances the formation of blood stem cell precursors from pluripotent stem cells. It’s knowledge we can use in the future. The next step in our research is to scale up the production of blood stem cell precursors, and to test their transplant potential in immune-deficient mice that can accept human transplants. We can do this by using large numbers of pluripotent stem cells grown in bioreactors that also mechanically stimulate blood stem cell formation. If we can easily produce blood stem cells from pluripotent stem cell lines, it would provide a plentiful supply of these cells to help treatments of cancer or genetic blood diseases. This article originally appeared on <a href="https://theconversation.com/scientists-have-mimicked-an-embryos-heart-to-unlock-the-secrets-of-how-blood-cells-are-born-190530" target="_blank" rel="noopener">The Conversation</a>. Image: UNSW

Body

"She sat on a throne of blood": Uni professor launches another attack on Queen Elizabeth

A controversial university professor has doubled down on her celebration of Queen Elizabeth's death, claiming she "sat on a throne of blood". Uju Anya, a linguistics professor at Pennsylvania's Carnegie Mellon University, <a href="https://oversixty.com.au/news/news/uni-professor-slammed-for-wishing-the-queen-excruciating-pain" target="_blank" rel="noopener">came under fire</a> earlier this week for a series of controversial tweets in which she hoped the Queen was in "excruciating pain" as she died. Now, the Nigerian-American lecturer has reiterated her claims on a podcast, saying, "This was a ruler. The very crown she had on her head signified the fact that she's a monarch was made from plunder. Diamonds. Blood diamonds." "The throne that she was sitting on is a throne of blood... Her very position as a monarch, the palace she lived in... were all paid for by our blood." She stood by her controversial tweets, which she admitted were an "emotional outburst", but said, "I said what I f****** said." "I was triggered by this news. It went deep into pain and trauma for me. Due to my family experience with the rule of this monarch." Anya also shared her thoughts on the Queen's role in the Nigerian Civil War in 1967 by showing support for the turbulent government. She said, "People expected me to be calm or to be... when the person who literally paid money for bombs and guns and military supplies to come and massacre your people is dying, you're not supped to dance." Anya's claims forced her employer to say in a statement, "We do not condone the offensive and objectionable messages posted by Uju Anya today on her social media account." "Free expression is core to the mission of higher education. However, the views she shared absolutely do not represent the values of the institution, nor the standards of discourse we seek to foster," they concluded. Despite thousands of people being up in arms over her comments and demanding an apology, others have jumped to the professor's defence. Over 4,000 people have signed a petition defending Anya, saying her posts on Twitter spoke to personal anguish the scholar still feels about atrocities by the British Empire decades ago that touched her family. Refusing to apologise, Anya once again tweeted, "If anyone expects me to express anything but disdain for the monarch who supervised a government that sponsored the genocide that massacred and displaced half my family and the consequences of which those alive today are still trying to overcome, you can keep wishing upon a star." Image credits: Getty Images / Youtube

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Anne Heche's blood test results revealed after horror smash

An investigation of Anne Heche’s blood results have detected “the presence of drugs” following <a href="https://www.oversixty.com.au/news/news/new-details-of-actor-anne-heche-s-fiery-crash" target="_blank" rel="noopener">her horror smash</a>. The US actress was pulled out of her burning car after she smashed into a mansion in Los Angeles while driving a terrifying 140km/h on August 5. The 53-year-old suffered severe injuries and soon after the crash fell into a coma and has not regained consciousness since. Almost a week after the incident, a Los Angeles Police Department Public Information Officer confirmed there was a “presence of drugs” in Anne’s blood system. “Based on the blood draw, it revealed the presence of drugs, however additional testing is required to rule out any substances that were administered at the hospital as part of her medical treatment,” they told <a href="https://www.foxnews.com/entertainment/anne-heche-blood-test-revealed-presence-of-drugs" target="_blank" rel="noopener">Fox News Digital</a>. "Any secondary drugs [takes] up to 30 days for [a] secondary test to come back.” TMZ previously reported that Anne had cocaine in her system upon arrival at the hospital, but that is yet to be confirmed. The crash is currently being investigated by the LAPD who have confirmed that if Anne is found to have been drunk she would face significant charges. "If found intoxicated, [Heche] could be charged with misdemeanour DUI hit and run. No arrests have been made so far,” a representative said. Anne’s representative has confirmed that she is in an “extreme critical condition”. “She has a significant pulmonary injury requiring mechanical ventilation and burns that require surgical intervention,” her representative said. “She is in a coma and has not regained consciousness since shortly after the accident.” Image: Getty

Caring

Bride wears engagement ring with blood in it

A bride-to-be has caused quite a stir after sharing a photo of her engagement ring that apparently has her fiancé’s blood in it. The woman shared the photo to the popular Facebook group “That's it, I'm wedding shaming” and at first glance it looks like a normal ring with a red stone. To everyone’s shock, she revealed that the “red stone” was in fact her fiancé’s blood. “Has anyone else opted out of a wedding band? I love my engagement ring so much, it has my fiancé’s blood in it and it is so special to me,” she began. “I’d rather that be put on my finger at the wedding instead of a band. I would have to get a custom one to fit my ring and I don’t know, I just don’t want to.” However, the comments were not nice about the $300 ring, with many questioning why anyone would do that. “I’m glad she loves it and is happy. It is heinous though,” one wrote. “I’m fine with one ring…as long as it’s not filled with BLOOD! What in the actual f**k?” someone else commented. "I hate it here," another simply wrote. Image: Facebook

Relationships

Man donates blood an incredible 600 times

A man has made an extraordinary accomplishment of saving more than 1,800 lives after donating blood 600 times. Bruce from Port Macquarie was egged on by his Aunty Mary after she had donated blood 70 times saying he would not be able to do as much as she did. But, Bruce being Bruce, he decided to accept his aunt's challenge and went ahead to donate blood. “My Aunty Mary told me she had done 70 donations, and that I would never catch her,” he said. “Smart lady, that one and the challenge was accepted.” Bruce, 60, now skateboards to an Australian Red Cross donation centre every fortnight to give generously. Since starting his blood donation, Bruce has become the first person in Port Macquarie – and one of only 60 people in Australia – to have donated blood a whopping 600 times. All those blood donations have contributed to saving the lives of up to 1,800 people including new mothers, babies, cancer patients and trauma sufferers. When asked for advice and encouragement on the process of donating, Bruce explained that it was a rewarding experience. “The vampires at [Lifeblood] are lovely and it doesn't hurt much at all, so I encourage others to put something back, roll up your sleeves and save a life,” he said. Bruce commended his Aunty Mary, saying that without her support he would not have reached the incredible milestone. Image: Australian Red Cross Lifeblood

Body

See the strawberry moon that shone around the world

Stargazers across the world had plenty to see this week, as the strawberry supermoon lit up the sky. The moon appeared slightly larger than usual with an orange tint, reaching its peak size on Wednesday night for Australia and New Zealand. Though called a strawberry moon, the name has nothing to do with colour, instead coming from the Native American Algonquin nations and meaning it is the last full moon in spring or first of summer in the northern hemisphere, per <a href="https://www.cbsnews.com/news/strawberry-supermoon-2022/" target="_blank" rel="noopener">CBS News</a>. According to <a href="https://www.almanac.com/content/full-moon-june" target="_blank" rel="noopener">The Old Farmer’s Almanac</a>, it was named the strawberry moon to mark the ripening of strawberries that would be ready to gather in June. Since it is a supermoon, defined as a full moon within 10 percent of the closest distance it can be to Earth, the moon appeared full in the days prior and will for a few more after, according to <a href="https://www.space.com/strawberry-supermoon-full-moon-2022-what-to-expect" target="_blank" rel="noopener">Space.com</a>. Here, we've compiled a collection of the most stunning shots of the supermoon from all corners of the world for your viewing pleasure. Image: Gary Hershorn (Getty Images)

International Travel

Genetic mutations slowly accumulated over a lifetime change blood production after 70 years of age

Ageing is likely caused by the gradual accumulation of molecular damage, or genetic mutations, in the cells of our bodies that occurs over a lifetime. But how this translates into the rapid deterioration in organ function that’s seen after the age of 70 has so far not been clear. Now, scientists have discovered that the accumulation of genetic mutations in blood stem cells are likely responsible for the abrupt change in how <a class="spai-bg-prepared" href="https://cosmosmagazine.com/science/biology/why-do-we-have-blood/" target="_blank" rel="noreferrer noopener">blood</a> is produced in the body after 70 years of age. The <a class="spai-bg-prepared" href="https://www.nature.com/articles/s41586-022-04786-y" target="_blank" rel="noreferrer noopener">new study</a>, published in Nature, points to a change in the diversity of stem cells that produce blood cells as the reason why the prevalence of reduced cell regeneration capacity, <a class="spai-bg-prepared" href="https://www.frontiersin.org/articles/10.3389/fonc.2020.579075/full" target="_blank" rel="noreferrer noopener">cytopenia</a> (one or more blood cell types is lower than it should be), immune disfunction, and risk of blood cancer dramatically rises after 70. “We’ve shown, for the first time, how steadily accumulating mutations throughout life lead to a catastrophic and inevitable change in blood cell populations after the age of 70,” says joint-senior author Dr Peter Campbell, head of the Cancer, Ageing and Somatic Mutation Program at the Wellcome Sanger Institute, UK. “What is super exciting about this model is that it may well apply in other organ systems too.” Blood cells are made in a process called haematopoiesis All of the cells in our blood – including red cells, white cells and platelets – develop in a process called haematopoiesis from haematopoietic stem cells in our bone marrow. These stem cells are what’s known as multipotent progenitor cells, which simply means that they can develop into more than one cell type. Researchers were interested in better understanding how this process changes as we age, so they sequenced the entire genomes of 3,579 haematopoietic stem cells from a total of 10 people – ranging in age from newborn to 81 years. <div class="newsletter-box spai-bg-prepared"> <div id="wpcf7-f6-p193434-o1" class="wpcf7 spai-bg-prepared" dir="ltr" lang="en-US" role="form"> <form class="wpcf7-form mailchimp-ext-0.5.61 spai-bg-prepared init" action="/science/mutations-change-blood-production/#wpcf7-f6-p193434-o1" method="post" novalidate="novalidate" data-status="init"> <input class="wpcf7-form-control wpcf7-text referer-page spai-bg-prepared" name="referer-page" type="hidden" value="https://www.google.com/" data-value="https://www.google.com/" aria-invalid="false" /> </form> </div> </div> Using this information, they were able to construct something similar to a family tree (<a class="spai-bg-prepared" href="https://www.nature.com/scitable/topicpage/reading-a-phylogenetic-tree-the-meaning-of-41956/#:~:text=A%20phylogenetic%20tree%2C%20also%20known,genes%20from%20a%20common%20ancestor." target="_blank" rel="noreferrer noopener">a phylogenetic tree</a>) for each stem cell, showing how the relationships between blood cells changes over the human lifespan. They found that in adults under 65, blood cells were produced from between 20,000 and 200,000 different stem cells – each contributing roughly equal amounts to production. But after 70 years of age they observed a dramatic decrease in the diversity of stem cells responsible for haematopoiesis in the bone marrow. In fact, only 12-18 independent expanded sets of stem cell clones accounted for 30-60% of cell production. These highly active stem cells had outcompeted others and progressively expanded in numbers (clones) across that person’s life, and this expansion (called <a class="spai-bg-prepared" href="https://www.nature.com/articles/s41586-022-04785-z" target="_blank" rel="noreferrer noopener">clonal haematopoiesis</a>) was caused by a rare subset of mutations known as driver mutations that had occurred decades earlier. “Our findings show that the diversity of blood stem cells is lost in older age due to positive selection of faster-growing clones with driver mutations. These clones ‘outcompete’ the slower growing ones,” explains lead researcher Dr Emily Mitchell, a haematology registrar at Addenbrooke’s Hospital,UK, and PhD student at the Wellcome Sanger Institute, US. “In many cases this increased fitness at the stem cell level likely comes at a cost – their ability to produce functional mature blood cells is impaired, so explaining the observed age-related loss of function in the blood system.” Which clones became the dominant stem cells varied between individuals, which explains why variation is seen in disease risk and other characteristics in older adults. “Factors such as chronic inflammation, smoking, infection and chemotherapy cause earlier growth of clones with cancer-driving mutations. We predict that these factors also bring forward the decline in blood stem cell diversity associated with ageing,” says joint-senior author Dr Elisa Laurenti, assistant professor at the Wellcome-MRC Cambridge Stem Cell Institute, UK. “It is possible that there are factors that might slow this process down, too,” she adds. “We now have the exciting task of figuring out how these newly discovered mutations affect blood function in the elderly, so we can learn how to minimise disease risk and promote healthy ageing.”  <img id="cosmos-post-tracker" class="spai-bg-prepared" style="opacity: 0; height: 1px!important; width: 1px!important; border: 0!important; position: absolute!important; z-index: -1!important;" src="https://syndication.cosmosmagazine.com/?id=193434&title=Genetic+mutations+slowly+accumulated+over+a+lifetime+change+blood+production+after+70+years+of+age" width="1" height="1" />  <div id="contributors"> <a href="https://cosmosmagazine.com/science/mutations-change-blood-production/" target="_blank" rel="noopener">This article</a> was originally published on <a href="https://cosmosmagazine.com" target="_blank" rel="noopener">Cosmos Magazine</a> and was written by <a href="https://cosmosmagazine.com/contributor/imma-perfetto" target="_blank" rel="noopener">Imma Perfetto</a>. Imma Perfetto is a science writer at Cosmos. She has a Bachelor of Science with Honours in Science Communication from the University of Adelaide. Image: Getty Images </div>

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Centenarian blood tests give hints of the secrets to longevity

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The Dark Side of the Moon at 50: how Marx, trauma and compassion all influenced Pink Floyd’s masterpiece

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Big study shows that lowering blood pressure lowers risk of dementia

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Scientists have mimicked an embryo’s heart to unlock the secrets of how blood cells are born

"She sat on a throne of blood": Uni professor launches another attack on Queen Elizabeth

Anne Heche's blood test results revealed after horror smash

Bride wears engagement ring with blood in it

Man donates blood an incredible 600 times

See the strawberry moon that shone around the world

Genetic mutations slowly accumulated over a lifetime change blood production after 70 years of age

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Centenarian blood tests give hints of the secrets to longevity

The US just returned to the Moon after more than 50 years. How big a deal is it, really?

8 reasons everyone should know their blood type

"I've lost complete blood flow": Robert Irwin's near miss with python

Worried about getting a blood test? 5 tips to make them easier (and still accurate)

Almost half of Moon missions fail. Why is space still so hard?

No, you can’t reverse ageing by injecting ‘young blood’ and fasting. But that doesn’t stop people trying

Leo DiCaprio's new film gets 9-minute standing ovation

Molly Meldrum “moons” crowd again

The Dark Side of the Moon at 50: how Marx, trauma and compassion all influenced Pink Floyd’s masterpiece

“A naughty boy who needs a new belt”: Molly Meldrum’s excuse for mooning Elton John’s crowd

Big study shows that lowering blood pressure lowers risk of dementia

Shehan Karunatilaka wins Booker prize for Sri Lankan political satire, The Seven Moons of Maali Almeida

Scientists have mimicked an embryo’s heart to unlock the secrets of how blood cells are born

"She sat on a throne of blood": Uni professor launches another attack on Queen Elizabeth

Anne Heche's blood test results revealed after horror smash

Bride wears engagement ring with blood in it

Man donates blood an incredible 600 times

See the strawberry moon that shone around the world

Genetic mutations slowly accumulated over a lifetime change blood production after 70 years of age

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